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PLoS ONE 8 , e71411 (2013)

In their experiment, Song et al

Thus, once MTHFR has reduced 5,10-methyleneTHF to 5-MTHF, the Vitamin B12 dependent methionine synthase, encoded by MTR, uses this reduced folate to convert Hcy back into methionine

This was in addition to the counteracted elongation of the QT interval and the known antiarrhythmic effect [30,31,54,56,57,58,59,60,61]

In fact, reports of bacterial endotoxin in the pelvic cavity and menstrual blood of people with endometriosis 37 have led to a bacterial contamination hypothesis suggesting endotoxin/bacteria in the menstrual effluent contributes to pelvic inflammation, growth, and progression of endometriotic lesions (reviewed in 38,39 )